![]() Furthermore, the quality of evidence for total efficacy was considered low or very low according to the GRADE tool.Ĭonclusion: HM can be considered as an effective and safe treatment for IBS. According to AMSTAR 2, the methodological quality of the included SRs was extremely low. The rate of adverse events was significantly lower with HM compared to CM, and no serious adverse events were reported with HM treatment. HM showed a more significant effect than CM in relieving independent IBS symptom score (abdominal pain score, diarrhea score, abdominal distension score, stool frequency score, etc.) and recurrence rate. In terms of total efficacy, HM was more effective than placebo, CM, or probiotics. Among them, eight SRs reported only specific subtypes of IBS: six SRs reported patients with diarrhea-predominant IBS, and two SRs reported patients with constipation-predominant IBS. Results: Eighteen SRs were included in this overview. Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of evidence for each main finding. Two investigators independently extracted the data and assessed methodological quality using the Measure Tool to Assessment System Reviews 2 (AMSTAR 2). The effects of placebo, conventional medicine (CM), and probiotics were compared with those of HMs. SRs and/or meta-analyses on the use of HMs for IBS were included. Methods: SRs published up to January 2022 were searched using six electronic databases. This study aimed to investigate the methodology and quality of evidence of SRs, and to describe the current state of research and evidence for the treatment of IBS with HM. Therefore, several systematic reviews (SRs) have been conducted to assess the efficacy and safety of HM in IBS patients. Herbal medicines (HMs) are frequently used in the treatment of IBS. 3Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, South Koreaīackground: Irritable bowel syndrome (IBS) is a common disorder with abdominal pain and bowel habits changes.2Department of Clinical Korean Medicine, Graduate School of Kyung Hee University, Seoul, South Korea.1Department of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.Hyejin Jun 1,2 †, Seok-Jae Ko 1,2,3 †, Keumji Kim 2, Jinsung Kim 2,3 and Jae-Woo Park 1,2,3* ![]()
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